|
KMID : 0380020100250030265
|
|
Korean Journal of Biotechnology and Bioengineering
2010 Volume.25 No. 3 p.265 ~ p.270
|
|
|
Effect of Simvastatin on the Migration and Invasion of U-373-MG Cells
|
|
Kim Hwan-Gyu
|
|
|
Abstract
|
|
|
|
Simvastatins are widely used to reduce endogenous cholesterol synthesis and improve hypercholesterolemia. Also, simvastatin have been shown to induce both angiogenic and angiostatic responses. In this study, I attempted to resolve this controversy by studying the effects of simvastatin on the cell migration and invasion with the proteinases secretion and expression pattern. U-373-MG cells treated with low dose of simvastatin (0.001~0.5 μM) showed the induction of migration and invasion compared with the addition of a control buffer. On the contrary, high dose of simvastatin (1~20 μM) showed the reduction of migration and invasion compared with the addition of a control buffer. I also showed that simvastatin-regulated migrative and invasive phenotypes were consistent with the secretion and expression pattern of matrix metalloproteinase-2 (MMP-2), MMP-9 and plasmin.
|
|
|
KEYWORD
|
|
|
simvastatin, migration, invasion, MMP, plasmin
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|